Per-Oral Endoscopic Myotomy for Esophagogastric Junction Outflow Obstruction: A Multicenter Pilot Study

Esophagogastric junction outflow obstruction (EGJOO) is a rare but increasingly recognized diagnosis as described by The Chicago Classification of Esophageal Motility Disorders version 3.0 (version 3.0).1 On high-resolution manometry (HRM), EGJOO characterized increased integrated relaxation pressure (IRP) the lower esophageal sphincter (LES), yet with some preserved peristalsis.2–4 Little consensus exists on preferred therapeutic approach.3 Although conceptually per-oral endoscopic myotomy (POEM) should address measurable dysfunction in LES, few data exist to support this.5 Thus, we aimed evaluate safety and efficacy POEM for treatment symptomatic EGJOO.